International Journal of Current Innovations in Advanced Research

COMPARATIVE ANALYSIS OF AGRO-INDUSTRIAL BY-PRODUCTS AS FEED FOR BLACK SOLDIER FLY LARVAE: IMPLICATIONS FOR SUSTAINABLE LIVESTOCK FEED

2026-05-02T03:57:50-04:00

The increasing demand for sustainable feed has driven the search for fish meal alternatives. This study evaluated black soldier fly larvae reared on four agro-industrial by-products: soybean meal, broken rice, cottonseed cake, and rapeseed cake. Over 12 days, growth performance, feed conversion ratio, survival rate, and nutritional composition were analyzed. Soybean meal has emerged as the most balanced feed, achieving efficient conversion, robust growth, and high survival rates owing to its protein content. Broken rice showed strong growth potential but lower survival and feed efficiency. Cottonseed cake excelled in FCR but was limited by low survival rates, whereas rapeseed cake displayed a steady performance with moderate growth. This study fills this research gap by examining the available feed substrates and offering practical solutions for livestock farmers. This study discusses the input for agro-industries to shift to a circular economy, net zero, and sustainable production.

DEVELOPMENT AND VALIDATION OF A GREEN UV -SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF ACOTIAMIDE IN TABLET DOSAGE FORM USING WATER AS A GREEN SOLVENT

2026-08-16T08:51:10-04:00

This study describes the Development And Validation of an eco -friendly UV-Spectrophotometric method for the estimation of acotiamide in tablet formulation in accordance with ICH Q2(R1) guidelines. The main aim of this study was to develop simple, accurate, precise and rapid, cost-effective validation method using water as an eco friendly solvent. Water was used as a green solvent to minimize the use of hazardous organic solvents and support a sustainable analytical approach. The method was validated for linearity, accuracy, precision, specificity, Robustness, Ruggedness LOD,LOQ.An eco-friendly uv spectrophotometric method used for estimation of acotiamide in tablet formulations. In this method the λmax of acotiamide was determined by scanning the standard solution over the wavelength range of 200-400nm .The standard and sample solutions were prepared and their absorbance was measured using uv spectrophotometer .Acotiamide exhibited maximum absorbance at 217nm. This method obeyed Beer – lambert’s law and exhibits a good linearity over the concentration range of 3-11µg/ml with regression equation A = 0.0574C + 0.0836 And a correlation coefficient R² of 0.9999.The accuracy of method was evaluated by recovery studies the percentage recovery was found in the range of 99.0%-99.2 %and the method demonstrated good precison the %RSD values were found to be less than 2%. Based on the above results the eco friendly UV spectrophotometric validation method is suitable for routine quality control analysis. The developed method is suitable for routine quality control analysis and assay determination of acotiamide tablets.

Development and Validation of New RP-HPLC Method for the Simultaneous Estimation of Delamanid and Bedaquiline in Combined Pharmaceutical Dosage Forms

2026-08-16T08:51:04-04:00

A simple, accurate, precise, and economical RP-HPLC method was developed and validated for the simultaneous estimation of Delamanid and Bedaquiline in bulk drug and pharmaceutical dosage forms. Chromatographic separation was achieved using a Kromasil C18 column (150 × 4.6 mm, 5.0 µm) with a mobile phase consisting of 0.01 N ammonium acetate buffer and acetonitrile in the ratio of 60:40 % v/v. The mobile phase was pumped at a flow rate of 1.0 mL/min, and the column temperature was maintained at 30°C. The ammonium acetate buffer was prepared by adding 0.1% acetic acid and adjusting the pH to 4.0. The optimized detection wavelength was 220 nm. The retention times of Delamanid and Bedaquiline were found to be 2.249 and 2.970 min, respectively. The percentage RSD for Delamanid and Bedaquiline was found to be 1.4% and 0.5%, respectively, indicating good precision. The percentage recovery was found to be 99.69% for Delamanid and 99.90% for Bedaquiline. The LOD and LOQ values obtained from the regression equations were 0.10 and 0.30 for Delamanid and 0.25 and 0.74 for Bedaquiline, respectively. The assay results were found to be 99.52% for Delamanid and 99.95% for Bedaquiline. The regression equations were y = 19629x + 3362.1 for Delamanid and y = 23316x + 9810.4 for Bedaquiline. The developed method provided short retention times and reduced total analysis time, making it simple, rapid, economical, and suitable for routine quality control analysis of Delamanid and Bedaquiline in pharmaceutical industries.

RECENT TRENDS IN MODIFIED TRANSDERMAL PATCHES

2026-03-24T03:09:59-04:00

Transdermal drug delivery has emerged as a promising alternative to oral and injectable routes, offering non-invasive, convenient, and controlled drug administration. Modified transdermal patches enhance traditional systems by incorporating technologies such as microneedles, iontophoresis, nano-carriers, and smart responsive materials. These innovations improve drug permeation, bioavailability, and therapeutic efficiency while minimizing systemic side effects. Recent trends focus on delivering a wider range of drugs, including hormones, peptides, proteins, vaccines, and small molecules. Microneedle-based patches allow painless administration of macromolecules previously unsuitable for transdermal delivery. Nanotechnology integration improves solubility, stability, and controlled release of drugs. Smart patches with sensors nable real-time monitoring and personalized drug release for chronic diseases like diabetes and cardiovascular disorders. Current research emphasizes customization, patient adherence, and long-term therapy effectiveness. Transdermal systems now target neurological, psychiatric, dermatological, and immunotherapeutic applications. Clinical studies demonstrate improved pharmacokinetics Advanced fabrication techniques, including 3D printing.

MICROEMULSIONBASED DELIVERY SYSTEMS FOR PHYTOCHEMICAL COMPOUNDS: FORMULATION STRATEGIES AND BIOMEDICAL APPLICATIONS

2026-07-03T14:35:51-04:00

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