PHYTOSOMES AS AN INNOVATIVE TECHNIQUE IN NOVEL DRUG DELIVERY SYSTEM: A COMPREHENSIVE REVIEW

Rajendra Kumar; Kapil Kumar; Deepak Teotia; Ikram; Deepti Khairya; Aparna Joshi

Authors

Rajendra Kumar Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India
Kapil Kumar Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India
Deepak Teotia Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India
Ikram Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India
Deepti Khairya Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India
Aparna Joshi Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India

Keywords:

Phytosomes, phospholipids, bioavailability

Abstract

Phytosomes are novel form of herbal formulations which contains the bioactive phytoconstituent(s) of herb extract complexed with phospholipid to produce lipid compatible molecular complexes. Since phytoconstituents are obtained from natural resources, fewer side effects and lower phytochemical costs are added advantages for their utilization in treatment of various diseases. Unfortunately, despite the wide therapeutic potentials of poly phenolic phytoconstituents such as flavonoids, glycosides, terpenoids etc. still they suffer with poor aqueous solubility, absorption and bioavailability problems when administered orally or by topical applications. The objective of this review is to focus on the application of phytosome technology along with its preparation, various properties and characterization. The recent development and conducted works of various researchers have been studied thoroughly to establish the transdermal route as a potential way to deliver phytoconstituents. Plant derived products or plant extracts are increasingly receiving attention as dietary supplements for the homeostatic management of inflammation, toxicities, cancers, weight loss and other chronic or acute degenerative disorders. But these products frequently face stability and bioavailability problems. Plant products after their isolation become prone to instability and are potentially unfit to cross the biomembrane as such. Some plant products show hydrophobicity and their delivery to systemic circulation is a quite difficult task.

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