Current methods for inranasal drug delivery based on nanotechnology for brain targeting

Ambika N

Authors

N.Ambika Priyadarshini Institute of Pharmaceutical Education and Research, 5th mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India

Keywords:

Nasal drug delivery system, Intranasal route, Nano technology, brain disorder

Abstract

Intranasal drug delivery is as a noninvasive and efficient approach extensively utilized for treating the local, central nervous system, and systemic diseases. Recent advancements in nanotechnology-based intranasal delivery systems have shown potential to enhance drug bioavailability, improve brain targeting, and overcome limitations associated with conventional delivery methods. As nanotechnology utilization in drug delivery has rapidly spread out, the nasal delivery has become attractive as a promising approach. The use of lipid-based nanoparticles, including nano/microemulsions, liposomes, solid lipid nanoparticles, and nano structured lipid carriers, has shown promise in enhancing the efficiency of nose-to-brain delivery. These nanoparticles facilitate drug absorption from the nasal membrane. Additionally, the in situgel (ISG) system has gained attention owing to its ability to extend the retention time of administered formulations within the nasal cavity. The anatomical and physiological considerations of the nasal cavity, particularly the olfactory and trigeminal nerve pathways, provide direct routes to the brain. Overall, this review furnishes a perspective aimed at galvanizing future research and development concerning intranasal drug delivery.

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