Advancement in lipid based nanoparticels for cancer treatment

Padmavathi Devi Neeluru

Authors

Neeluru. Padmavathi Devi Priyadarshini Institute of Pharmaceutical Education and Research 5th Mile, Pulladigunta, Guntur-522017. Andhra Pradesh, India

Keywords:

Nanoparticle, Cancer Treatment, Lipid Based Drug Delivery, Cancer Cells

Abstract

This review evaluates the literature on nanoparticle-based drug delivery systems for cancer treatment and assesses their efficacy. Nanoparticles have shown potential for improving anticancer agent delivery, reducing systemic toxicity, and enhancing therapeutic outcomes. Extensive studies have shown promising results in preclinical and clinical trials. Therefore, a novel paradigm with concomitant imaging (with contrasting agents), targeting (with biomarkers), and anticancer agent being delivered in one lipidic nanocarrier system (as cancer theragnostic) seems to be very promising in overcoming various hurdles in effective cancer treatment. The major obstacles that are supposed to be addressed by employing lipidic theragnostic nanomedicine include nanomedicine reach to tumour cells, drug internalization in cancer cells for therapeutic intervention, off-site drug distribution, and uptake via the host immune system. A comprehensive account of recent research updates in the field of lipidic nanocarrier loaded with therapeutic and diagnostic agents is covered in the present article. Nevertheless, there are notable hurdles in the clinical translation of the lipidic theragnostic nanomedicines, which are also highlighted in the present review along with plausible countermeasures.

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