FLOATING DRUG DELIVERY SYSTEM: AN UPDATED REVIEW

Pradeep Kumar; Deepti Khairya; Deepak Teotia; Vaishali Rajpoot

Authors

Pradeep Kumar Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India
Deepti Khairya Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India
Deepak Teotia Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India
Vaishali Rajpoot Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India

Keywords:

Floating drug delivery systems, gastric residence time, effervescent

Abstract

Incorporation of the drug in a controlled release gastroretentive dosage forms (CR-GRDF) which can remain in the gastric region for several hours would significantly prolong the gastric residence time of drugs and improve bioavailability, reduce drug waste, and enhance the solubility of drugs that are less soluble in high pH environment. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices. In this review, current & recently developments of Stomach Specific FDDS are discussed that helps to overcome physiological adversities like short gastric residence times and unpredictable gastric emptying times. The purpose of writing this review on floating drug delivery system which is also known as hydrodynamically controlled systems (FDDS) was to compile the recent literature with special focus on Classification, Mechanism of Action and Evaluation of floating drug delivery system.

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References

Chanchal K, A Roy. Floating Drug Delivery System for Analgesic - A Review, Bachelor of Dental Surgery, Faculty of Pharmacology, Saveetha Dental College and Hospital, Chennai, India. 12-02-2017

Singh, A., Srinivasan, A.K., Chakrapani, L.N. and Kalaiselvi, P., 2019. LOX-1, the common therapeutic target in hypercholesterolemia: a new perspective of antiatherosclerotic action of aegeline. Oxidative medicine and cellular longevity, 2019.

Uppugalla S, Male U, Srinivasan P. Design and synthesis of heteroatoms doped carbon/polyaniline hybrid material for high performance electrode in supercapacitor application. Electrochimica Acta. 2014 Nov 10;146:242-8.

Radwan MA, Abou el Ela AE, Hassan MA, El-Maraghy DA. Pharmacokinetics and analgesic effect of ketorolac floating delivery system. Drug delivery. 22(3), 2015 Apr 3, 320-7.

Avinash K, Abha D, Praween K, Abhinav G. 11. Floating Drug Delivery System a Significant Tool for Stomach Specific Release of Cardiovascular Drugs. International Journal of Drug Development and Research. 2012.

Verma BK, Pandey S, Arya P. Tablet granulation: current scenario and recent advances. Universal Journa of Pharmaceutical Research 2017; 2(5): 30-35.

Male U, Uppugalla S, Srinivasan P. Effect of reduced graphene oxide–silica composite in polyaniline: electrode material for high-performance supercapacitor. Journal of Solid State Electrochemistry. 2015 Nov;19(11):3381-8.

Singh, A., Gowtham, S., Chakrapani, L.N., Ashokkumar, S., Kumar, S.K., Prema, V., Bhavani, R.D., Mohan, T. and Sathyamoorthy, Y.K., 2018. Aegeline vs Statin in the treatment of Hypercholesterolemia: A comprehensive study in rat model of liver steatosis. Functional Foods in Health and Disease, 8(1), pp.1-16.

Agnihotri SA, Jawalkar SS, Aminabhavi TM. (2006). Controlled release of cephalexin through gellan gum beads: Effect of formula-tion parameters on entrapment efficiency, size, and drug release, Eur. J. Pharm. Biopharm. 63:249-261. DOI PMid:16621483

Algin Yapar E, Beskan U, Karavana Sy. A recent overview of locally administered topical otic dosage forms. Universal Journal of Pharmaceutical Research 2019; 4(4): 39-42.

Babu VBM, Khar RK. (1990). In vitro and In vivo studies of sustained release floating dosage forms containing salbutamol sulphate. Pharmazie.; 45: 268-270. PMid:2381979

Desai S, Bolton S. (1993). A floating controlled release drug delivery system: in vitro- in vivo evaluation. Pharm Res; 10(9): 1321-1325. DOI PMid:8234170

Singh, A., Kumar, A. and Kalaiselvi, P., 2018. Aegeline, targets LOX1, the receptor for oxidized LDL to mitigate hypercholesterolemia: a new perspective in its anti-atherosclerotic action. Free Radical Biology and Medicine, 128, p.S41.

Tripathi GK, Singh S: Formulation and In vitro evaluation of pH sensitive oil entrapped polymeric blended buoyant beads of Amoxicillin. Scholars Research Library 2010; 2 (2): 131-38.

Uppugalla S, Srinivasan P. High-performance supercapacitor coin cell: polyaniline and nitrogen, sulfur-doped activated carbon electrodes in aqueous electrolyte. Journal of Solid State Electrochemistry. 2019 Jan;23(1):295-306.

Al-kaf AGA, Othman AM. Pharmacosomes: an Updated review, Universal Journal of Pharmaceutical Research 2017; 2(1): 30-33.

Kharia AA, Hiremath SN, Singhai AK and Jain SK: Design and optimization of floating drug delivery system of acyclovir. Indian Journal of Pharmaceutical Sciences 2010; 72(5): 599-06.

Uppugalla S, Srinivasan P. Polyaniline nanofibers and porous Ni [OH] 2 sheets coated carbon fabric for high performance super capacitor. Journal of Applied Polymer Science. 2019 Nov 5;136(41):48042.

Abhilasha, S., Narasimhan, C.L., Kumar, S.A., Kumar, S.N.K., Bhavani, R.D., Thangarajeswari, M., Prema, V. and Kalaiselvi, P., 2017. Ethanolic extract of aegle marmelos mediates its hypocholesterolemic effect by retarding circulatory oxidized ldl formation via 12/15 lipoxygenase pathway.

Kumar K, Rai AK. Development and evaluation of floating microspheres of herbal drugs. Tropical Journal of Pharmaceutical Research. 2012; 11(5), 713-719.

Singh, A., 2022. Role of microbial metabolites in cardiovascular and human health. In Microbiome, Immunity, Digestive Health and Nutrition (pp. 137-148). Academic Press.

Setia M, Kumar K, Teotia D. Development and evaluation of gastro-retentive floating beads of dicycloverine hydrochloride, Journal of Drug Delivery and Therapeutics. 2018; 8(4):346-355.

Sunday OS. Colon-targeted drug delivery systems: design, trends and approaches. Universal Journal of Pharmaceutical Research 2017; 2(4): 46-50.

Uppugalla S, Boddula R, Srinivasan P. Methyl triphenylphosphonium permanganate as a novel oxidant for aniline to polyaniline-manganese (II, IV) oxide: material for high performance pseudocapacitor. Journal of Solid State Electrochemistry. 2018 Feb;22(2):407-15.

Mantry S, Thilothama LR and Shashanka D: Formulation and in vitro evaluation of Metoprolol Succinate Floating Tablets by using two viscosity grade of HPMC. International Journal of Pharmaceutical Sciences and Research 2012; 3(9): 3507-13.

Shiv Chandra Singh, A., Yu, A., Chang, B., Li, H., Rosenzweig, A. and Roh, J.D., 2021. Exercise Training Attenuates Activin Type II Receptor Signaling in the Aged Heart. Circulation, 144(Suppl_1), pp.A14259-A14259.

Kaur G, Paliwal S. Formulation and evaluation of etoricoxib microbeads for sustained drug delivery. Universal Journal of Pharmaceutical Research 2019; 4(1): 35-39.

Singh, A., 2022. Role of microbial metabolites in cardiovascular and human health. In Microbiome, Immunity, Digestive Health and Nutrition (pp. 137-148). Academic Press.

Singh BN, Kim KH. Floating drug delivery system: An approach to the controlled drug delivery via gastric retention. J Control Release 2000; 63: 235‐259.

Roh, J., Hill, J.A., Singh, A., Valero-Muñoz, M. and Sam, F., 2022. Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models. Circulation Research, 130(12), pp.1906-1925.

Felix Sunday Yusuf. Formulation and in-vitro evaluation of floating microballoons of

stavudine. Universal Journal of Pharmaceutical Research. 2016; 1(1): 13-19.

Arora S, Ali A, Ahuja A, Khar RK, Baboota S. Floating drug delivery systems: A review. AAPS PharmSciTech 2005; 6(3): E372‐ E390.

Tanwar YS, Naruka PS, Ojha GR. Development and evaluation of floating microspheres of verapamil hydrochloride. Brazilian J of Pharm Sci 2007; 43: 529‐534.

Boini, K.M., singh, A. and Koka, S.S., 2021. Gut Microbial Metabolite Trimethylamine N-oxide Enhances Endoplasmic Reticular Stress and Promotes Endothelial Dysfunction. Circulation, 144(Suppl_1), pp.A14071-A14071.

Setia M, Kumar K, Teotia D. Gastro-retentive floating beads a new trend of drug delivery system. Journal of Drug Delivery andTherapeutics. 2018; 8(3): 169-180.

Kumar K, Rai AK. Evaluation of anti-inflammatory and anti-arthritic activities of floating microspheres of herbal drug, International research journal of pharmacy. 2012; 3(1):186-193.

Anyanwu NCJ, Adogo LY, Ajide B. Development and evaluation of in situ gelling gastroretentive formulations of Meloxicam. Universal Journal of Pharmaceutical Research. 2017; 2(3): 11-14.

Roh, J.D., Kitchen, R.R., Guseh, J.S., McNeill, J.N., Aid, M., Martinot, A.J., Yu, A., Platt, C., Rhee, J., Weber, B. and Trager, L.E., 2022. Plasma proteomics of COVID-19–associated cardiovascular complications: implications for pathophysiology and therapeutics. Basic to Translational Science, 7(5), pp.425-441.

W Sawicki, Pharmacokinetics of verapamil and nor verapamil from controlled release floating pellets in humans. Eur J Pharm Biopharm; 2002; 53; 29-35.

Ikechukwu UR, John Francis DE, Ambi AA. Development and evaluation of Ritonavir hollow microballoons for floating drug delivery. Universal Journal of Pharmaceutical Research. 2017; 2(2): 30-34.

Singh BM, Kim KH Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control Release 2000; 63:235-259.

Jain SK, Agarwal GP, Jain NK. Evaluation of porous carrier based floating orlistat microspheres for gastric delivery. AAPS PharmSciTech; 2006:7(4)

Baumgartner S, Kristl J, Vrecer F. Optimization of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm 2000; 195: 125‐135.

Shaikh SC, Sanap D, Bhusari DB, Jain S, Kochar PP, Sanchati VN. Formulation and evaluation of Ibuprofen gastro-retentive floating tablets. Universal Journal of Pharmaceutical Research. 2018; 3(4): 20-25.

Kumar K, Rai AK. Floating Microsphere: An innovative Approach for Gastro retention. Journal of Pharmacy Research. 2012; 5(2):883-886.