Synthesis, Characterization and Evaluation of Antibacterial Activity of a New Phenylmethylidene Thiourea Derivative and Its Copper (Ii) Complex

Samarasinghe W.M.P; Sithambaresan M; Mahendranathan C

Authors

Samarasinghe, W.M.P Department of Chemistry, Faculty of Science, Eastern University, Sri Lanka.
Sithambaresan, M Department of Chemistry, Faculty of Science, Eastern University, Sri Lanka.
Mahendranathan, C Department of Botany, Faculty of Science, Eastern University, Sri Lanka.

Keywords:

Antibacterial activity, Copper complex, Thiourea derivatives

Abstract

A new thiourea derivative was synthesized by the condensation reactions of thiourea with benzaldehyde in ethanol. The copper complex was prepared from the reactions of the copper chlorides with newly synthesized phenylmethylidene thiourea derivative. The progress of the reaction was monitored by TLC using water - ethanol as solvent for every 30 minutes. The new ligand and its copper complex were characterized by UV- Visible spectroscopy and IR spectroscopy. The melting point of the synthesized ligand and it copper complex were determined and conductivity of the complex was measured. Synthesized ligand and the complex were screened for antimicrobial activity against two bacteria strains Escherichia coli, and Staphylococcus aureus using agar diffusion disc method.

Downloads

Download data is not yet available.

References

Abdullah, B.H. and Salh, Y.M. 2010. Synthesis, characterization and biological activity of N-phenylÑ-(2-phenolyl)thiourea (PPTH) and its metal complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Pd(II), Pt(II) and Hg(II). Oriental Journal of Chemistry, 26(3): 763-773.

Ajibade, P.A. and Zulu, N.H. 2011. Metal Complexes of Diisopropylthiourea: Synthesis, Characterization and Antibacterial Studies. Int. J. Mol. Sci., 12: 7186-7198.

Anjaneyulu, Y. and Prabhakara Rao, R. 1986. Preparation, Characterization and Antimicrobial Activity Studies on Some Ternary Complexes of Cu(II) with Acetylacetone and Various Salicylic Acids. Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 16(2): 257-272, DOI: 10.1080/00945718608057530.

Arslan, H., Duran, N., Borekci, G., Koray Ozer, C. and Akbay, C. 2009. Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes. Molecules., 14: 519-527.

Asieh Yahyazadeh and Zahra Ghasemi. 2013. Synthesis of Unsymmetrical Thiourea Derivatives. Eur.Chem. Bull., 2(8): 573- 575.

Badiceanu, C.D., Draghici, C. and Missir, A.V. 2010. Synthesis and Characterization of Some Biolodical Active Compounds on the Basis of 2-thiophene Carboxylic acid with Heterocyclic amines. Revue Roumaine de Chimie, 55(6): 307-311.

Bielenica, A., Struga, M., Mirosław, B., Kozioł, A.E., Kossakowski, J., Sanna, G., La Colla, P. and Giliberti, G. 2009. Synthesis and biological evaluation of N-substituted polycyclic imides derivatives. European J. Medicin. Chem., 44(12): 4960-4969.

Domnguez, M., Antico, E., Beyer, L., Aguirre, A., Garca-Granda, S. and Salvado, V. 2002. Liquid–liquid extraction of palladium(II) and gold(III) with N-benzoyl-N′,N′-diethylthiourea and the synthesis of a palladium benzoylthiourea complex. Polyhedron, 21(14-15): 1429-1437.

Jadhao, S.Z. and Rathod, M.S. 2012. Synthesis and Structural Investigation of Zinc Metal- Ligand (Thiourea Derivative) Complexes. J. Chem. Pharma. Res., 4(2): 1562-1565.

Lorenados Santosa, Luíse Azevedo Lima, Valdir Cechinel-Filho, RogérioCorrêa, Fátimade, Campos Buzzi and Ricardo JoséNunesa. 2018. Synthesis of new 1-phenyl-3-{4-[(2E)-3-phenylprop-2-enoyl] phenyl}-thiourea and urea derivatives with anti-nociceptive activity. Bioorg. Medic. Chem., 16(18): 8526-8534.

Madan, V., Taneja, A. and Kudesia, V. 1991. Synthesis an Spectral Studies of Some Pyrimidyl and Thiazolyl Substituted Thioureas as Potential Fungicides and Nematicides. J. Ind. Chem. Soc., 68(8): 471-472.

Md Yusof, E.N., Ravoof, T.B.S.A., Tiekink, E.R.T., Veerakumarasivam, A., Crouse, K.A., Mohamed Tahir, M.I. and Ahmad, H. 2015. Synthesis, Characterization and Biological Evaluation of Transition Metal Complexes Derived from N, S Bidentate Ligands. Int. J. Mol. Sci., 16: 11034-11054.

Mishra, A., Ninama, S., Sharma, P., Soni, N. and Awate, R. 2012. A newly Synthesis and characterization of metal complexes of 3-(N- phenyl) thiourea-pentanone-2 as ligand. Journal of Physics: Conference Series, 365(1): 365-372.

Moloto, M.J., Malikb, M.A., O'Brien, P., Motevallic, M. and Kolawolea, G.A. 2003. Synthesis and characterisation of some N-alkyl/aryl and N, N′-dialkyl/aryl thiourea cadmium (II) complexes: the single crystal X-ray structures of [CdCl2(CS(NH2)NHCH3)2. Polyhedron., 22(4): 595-603.