Toxicological Studies and Biodegradability Prediction of Isonicotinylhydrazide

Kamel Mokhnache; Soraya Madoui; Noureddine Charef

Authors

Kamel Mokhnache Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1,19000, Algeria.
Soraya Madoui
Noureddine Charef

Keywords:

toxicological, biodegradability, microorganisms, online software programs

Abstract

The antitubercular drug isonicotinylhydrazide (Isoniazid) was selected for toxicological and biodegradation studies. In silico ecotoxicological and biodegradability predictions were carried out online computer software programs such as Pro Tox, Pred-skin, Endocrine Disruptor Knowledge Base (EDKB) and UM-BBD. In silico predictions, results showed high toxicity of this drug; hepatoxicity with probability of 93%, carcinogenicity; 81% and without nephrotoxic effect. For biodegradability prediction, the results indicate the ability of microorganism to degrade the drug with no-toxic resultant products. We conclude the possibility to using the drug with high precautions from environment and human health.

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References

Pinedo-Rivilla, C., Aleu, J. and Collado, I.G. 2009. Pollutants biodegradation by fungi. Current Organic Chemistry, 13(12): 1194-1214.

Vorberg, S. and Tetko, I.V. 2014. Modeling the biodegradability of chemical compounds using the online CHEmical modeling environment (OCHEM). Molecular Informatics, 33(1): 73-85.

Vlădoiu, D.L., Filimon, M.N., Ostafe, V. and Isvoran, A. 2015. Effects of herbicides and fungicides on the soil chitinolytic activity. A molecular docking approach. Ecological Chemistry and Engineering S, 22(3): 439-450.

Księżopolska, A. and Joniec, J. 2014. Activity of Microorganisms Participating in Organic Matter Transformation in Haplic Luvisol Soil. Ecological Chemistry and Engineering S, 21(3): 499-514.

Nishino, S.F. and Spain, J.C. 1995. Oxidative pathway for the biodegradation of nitrobenzene by Comamonas sp. strain JS765. Applied and Environmental Microbiology, 61(6): 2308-2313.

Gupta, R.C. and Shukla, O.P. 1978. Metabolism of isoniazid and related compounds by microorganisms: isolation, characterization and growth of isoniazid-degrading organism. Indian Journal of Experimental Biology, 16(10): 1047-1051.

Chauhan, A. and Jain, R.K. 2000. Degradation of o-nitrobenzoate via anthranilic acid (o-aminobenzoate) by Arthrobacter protophormiae: a plasmid-encoded new pathway. Biochemical and Biophysical Research Communications, 267(1): 236-244.

Noguera, D.R. and Freedman, D.L. 1996. Reduction and Acetylation of 2, 4-Dinitrotoluene by a Pseudomonas aeruginosa Strain. Applied and Environmental Microbiology, 62(7): 2257-2263.

Nishino, S.F. and Spain, J.C. 1993. Degradation of nitrobenzene by a Pseudomonas pseudoalcaligenes. Applied and Environmental Microbiology, 59(8): 2520-2525.

Preuss, A., Fimpel, J. and Diekert, G. 1993. Anaerobic transformation of 2, 4, 6-trinitrotoluene (TNT). Archives of Microbiology, 159(4): 345-353.

Gupta, R.C. and Shukla, O.P. 1979. Microbial transformation of isonicotinic acid hydrazide and isonicotinic acid by Sarcina sp. Journal of Biosciences, 1(2): 223-234.

Jang, J.Y., Kim, D., Bae, H.W., Choi, K.Y., Chae, J.C., Zylstra, G.J., Kim, Y.M. and Kim, E. 2005. Isolation and characterization of a Rhodococcus species strain able to grow on ortho-and para-xylene. The Journal of Microbiology, 43(4): 325-330.

Liu, Z., Yang, H., Huang, Z., Zhou, P. and Liu, S.J. 2002. Degradation of aniline by newly isolated, extremely aniline-tolerant Delftia sp. AN3. Applied Microbiology and Biotechnology, 58(5): 679-682.

Schenzle, A., Lenke, H., Fischer, P., Williams, P.A. and Knackmuss, H. 1997. Catabolism of 3-Nitrophenol by Ralstonia eutropha JMP 134. Applied and Environmental Microbiology, 63(4): 1421-1427.

Broderick, J.B. and O'Halloran, T.V. 1991. Overproduction, purification, and characterization of chlorocatechol dioxygenase, a non-heme iron dioxygenase with broad substrate tolerance. Biochemistry, 30(29): 7349-7358.

Toyama, T., Momotani, N., Ogata, Y., Miyamori, Y., Inoue, D., Sei, K., Mori, K., Kikuchi, S. and Ike, M. 2010. Isolation and characterization of 4-tert-butylphenol-utilizing Sphingobium fuliginis strains from Phragmites australis rhizosphere sediment. Applied and Environmental Microbiology, 76(20): 6733-6740.

Nelson, M.J. and Snell, E.E. 1986. Enzymes of vitamin B6 degradation. Purification and properties of 5-pyridoxic-acid oxygenase from Arthrobacter sp. Journal of Biological Chemistry, 261(32): 15115-15120.

Fuchs, A. and De Vries, F.W. 1978. Bacterial breakdown of benomyl. II. Mixed cultures. Antonie van Leeuwenhoek, 44(3-4): 293-309.

Rather, L.J., Knapp, B., Haehnel, W. and Fuchs, G. 2010. Coenzyme A dependent aerobic metabolism of benzoate via epoxide formation. Journal of Biological Chemistry, 285(27): 20615-2024.

Zhao, J.S., Singh, A., Huang, X.D. and Ward, O.P. 2000. Biotransformation of hydroxylaminobenzene and aminophenol by Pseudomonas putida 2NP8 cells grown in the presence of 3-nitrophenol. Applied and Environmental Microbiology, 66(6): 2336-2342.

Watson, G.K., Houghton, C. and Cain, R.B. 1974. Microbial metabolism of the pyridine ring. The metabolism of pyridine-3, 4-diol (3, 4-dihydroxypyridine) by Agrobacterium sp. Biochemical Journal, 140(2): 277-292.

Lau, P.C., Bergeron, H., Labbé, D., Wang, Y., Brousseau, R. and Gibson, D.T. 1994. Sequence and expression of the todGIH genes involved in the last three steps of toluene degradation by Pseudomonas putida F1. Gene, 146(1): 7-13.

Sette, L.D., Da Costa, L.A.M.A., Marsaioli, A.J. and Manfio, G.P. 2004. Biodegradation of alachlor by soil streptomycetes. Applied Microbiology and Biotechnology, 64(5): 712-717.

Blakley, E.R. 1977. The catabolism of L-tyrosine by an Arthrobacter sp. Canadian Journal of Microbiology, 23(9): 1128-1139.